Host genetic polymorphisms associated with beta human papillomavirus seropositivity

Human papillomaviruses (HPVs) cause superficial epidermal infections and are only cleared if they trigger an immunological response. We analysed SNPs that had previously been investigated for association with HPV infection to determine whether play a role in the serological response cutaneous beta-HPVs Australian population. Serum samples from 1,142 participants were seropositivity against L1 protein of 21 beta-HPV types. Associations between types rs9264942 (HLA-C; HPV-9, p = 0.022, HPV-15, 0.043 HPV-17, 0.004), rs12449858 (EVER1; HPV-23, 0.029), rs2981451 (FGFR2; HPV-22, 0.049) identified. found certain could be involved beta-HPVs.